The main objective of the ZES (opportunity Zones for innovation EcosystemS governance) project is to build a logical framework for prioritizing public choices at city level towards Innovation Ecosystem (IE) rationale. The ZES project focuses on IEs governance and decision-making processes starting from the analysis of local assets – and their potentials – with respect the urban context to reinforce the urban dimension of S3 and Cohesion Policy for the next programming period.